Healthcare is continually challenged by needs to provide exceptional outcomes in patient safety, workforce safety, clinical quality, patient experience, and efficiency. This year has challenged us to the limit in continuing to provide exceptional care while protecting the physical and psychological safety of caregivers. Next year will likely be even more challenging as we work to recover the patient care we deferred during the pandemic and recover from the psychological harm to caregivers as well as fiscal harm to the systems. High-reliability and the related field of High Reliability Organizing (HRO) provide us help that is ready now to meet all these needs. This short and fast-moving program will examine the needs, provide a broad HRO solution that we should all be working on the next five years, and provide simple solutions that we as caregivers can use tomorrow – all with the potential to reduce loss events by 80% in two years.